E.J Young Comments on Isaiah 53:3

“He was despised and rejected by men;
a man of sorrows, and acquainted with grief;
and as one from whom men hide their faces
he was despised, and we esteemed him not.”

As the verse began so it concludes; hence Isaiah again employs the word despised, and adds to it the tragic statement, and we esteemed him not. Perhaps the purpose is to make even sharper the strong contrast in the following verse.

The unbelief that Isaiah here depicts is the same unbelief found all about us today. Men say pleasant and complimentary things about the Lord of Glory. They will praise His ethics, His teaching, declare that He was a good man and a great prophet, the only one who has answers to the social problems that today confront the world. They will not, however, acknowledge that they are sinners, deserving of everlasting punishment, and that the death of Christ was a vicarious sacrifice, designed to satisfy the justice of God and to reconcile an offended God to the sinner. Men will not receive what God says concerning His Son. Today also, the Servant is despised and rejected of men, and men do not esteem Him.

Isaiah Commentary, p. 344